MEDICAL MARVELS:MEDICAL MARVELS:ADDITIVE MANUFACTURING AND ADVANCEDADDITIVE MANUFACTURING AND ADVANCEDMATERIALS IN HEALTHCAREMATERIALS IN HEALTHCAREINSIGHT OUTi3D MFG and EOS InkAgreement for 12 EOS M 400-4 Industrial 3D PrintersTECHNOLOGY &PRODUCTSFEATURE STORYSiemens Healthineers OffersNew Way to Detect a BrokenHeart: NT‑proBNPII AssayNow Part of Atellica CardiacTesting Menu From Concept toFrom Concept toReality: The Journey ofReality: The Journey ofPrototyping in MedicalPrototyping in MedicalManufacturingManufacturingMr. Rockey Ye, Head ofMr. Rockey Ye, Head ofHygiene, Paper & CardboardHygiene, Paper & Cardboardat Bostik APACat Bostik APACGREATOPPORTUNITYWISH Launches 2024WISH Launches 2024Competition on Healthcare-Competition on Healthcare-Related InnovationRelated InnovationMr. Motoki Ohno, Head of Hygiene,Mr. Motoki Ohno, Head of Hygiene,Paper and Cardboard at Bostik JapanPaper and Cardboard at Bostik Japan
01Stratasys files patentinfringement lawsuitt...Stratasys, Inc., the original patent holderfor FDM (filament material extrusion)....02i3D MFG and EOS Ink Agreementfor 12 EOS M 400-4 Industrial...Integrated 3D (i3D MFG), one of thelargest metal additive manufacturing....033DEO Partners with IHIAerospace to Enhance Adoption...3DEO, headquartered in Los Angeles,California, USA, has announced a....05ADDiTEC partners with BharatFritz Werner to Revolutionize...ADDiTEC, a leading US-based additivemanufacturing company is proud to....05Tucker Induction Systems andNikon SLM Solutions Pioneer....Tucker Induction Systems, a leader inthe induction heating industry.....06Materialise and nTop Partner toPush the Boundaries of What’s...Collaboration yields high-performance3D-printed cylinder head for Wärtsilä...10Digitalization in Aerospace:Oerlikon and MTU Aero Engines...At the Farnborough InternationalAirshow 2024, Oerlikon and MTU Aero...11NAMI Selects 3D Systems’ Metal &Polymer Additive Manufacturing...3D Systems (announced that NationalAdditive Manufacturing & Innovation.....13Siemens and BAE Systems signfive-year agreement to....Siemens and BAE Systems haveannounced an agreement that will see...14The Korea Institute of MaterialsScience signed an MOU with....On July 23, the Korea Institute ofMaterials Science signed an MOU with....TABLE OF CONTENTSTABLE OF CONTENTSINSIGHT OUT
15US FDA expands Jemperli(dostarlimab) plus chemotherapy GSK announced the US Food and DrugAdministration (FDA) has approved.....16ExactCare and Tabula RasaHealthCare Rebrand Combined...Integrated 3D (i3D MFG), one of thelargest metal additive manufacturing....17Spectrum Dynamics Medical andHermes Medical Solutions Enter..3DEO, headquartered in Los Angeles,California, USA, has announced a....19Sarclisa induction treatmentdemonstrated significantly....New results from the two-part, double-randomized, German-speaking.....25Advances in polymers andmaterials for additive.....IMPC 2024: Advanced Materials forAdditive Manufacturing II: AM and...267th International Conference onHealthcare Service Management..Welcome to the 2024 7th InternationalConference on Healthcare Service....27MEDICAL FAIR ASIA3D Systems (announced that NationalAdditive Manufacturing & Innovation.....29WISH Launches 2024 Competitionon Healthcare-Related InnovationThe World Innovation Summit for Health(WISH), an initiative of Qatar....TECHNOLOGY & PRODUCTS20Fizik’s One-to-One CreatesCustom Saddles for Riders....Saddles are a crucial point of contactbetween riders and their bikes and can...23Siemens Healthineers Offers NewWay to Detect a Broken Heart:...Siemens Healthineers has added theNT‑proBNPII (PBNPII) assay to its.....GREAT OPPORTUNITY30MOH ESS Essay Competition 2024Interested in revolutionising healthcarethrough economics? Stand a chance....
FEATURE STORY323D Printing the Future ofHealthcare: Custom Solutions...3D printing is revolutionizing thehealthcare industry, offering....33From Concept to Reality: TheJourney of Prototyping in....Prototyping plays a crucial role inmedical manufacturing bridging,....35Packaging Precision—EnsuringSafety and Integrity in......As the pharmaceutical industrycontinues to innovate and expand,....37Mr. Rockey Ye, Head of Hygiene,Paper & Cardboard at BostikAPAC22 MINUTES39Mr. Motoki Ohno, Head ofHygiene, Paper and Cardboard atBostik Japan
ALL THE BESTWelcome to this edition ofIndustrial Guide Asia, where weexplore the transformativeinnovations shaping thehealthcare industry. In this issue,we delve into the fascinatingworld of Medical Marvels:Additive Manufacturing andAdvanced Materials inHealthcare.The future of healthcare isunfolding before our very eyes,driven by the remarkableadvancements in additivemanufacturing and cutting-edge materials. Frompersonalized prosthetics torevolutionary surgical implants,these technologies arerevolutionizing the way weapproach medical challenges.Additive manufacturing,commonly known as 3D printing,has opened up a realm ofpossibilities, allowing healthcareproviders to create customizedsolutions tailored to individualpatient needs. The ability torapidly prototype andmanufacture complex medicaldevices is empowering cliniciansto deliver more personalized andeffective treatments. This revolutionary technology istransforming various aspects ofhealthcare, from prosthetics tosurgical planning. With 3D printing, surgeons cannow create precise anatomicalmodels of a patient's organs,enabling them to rehearsecomplex procedures andoptimize surgical outcomes. Indentistry, custom-fit implantsand aligners are beingproduced with unprecedentedaccuracy, improving patientcomfort and treatmentefficacy. The potential for on-demand production ofmedical supplies in remote ordisaster-stricken areas isanother exciting application,potentially saving countlesslives. Moreover, researchersare exploring the possibility ofbioprinting living tissues andorgans, which could potentiallyaddress the critical shortage ofdonor organs and revolutionizetransplant medicine. As the technology continues toadvance, we can expect to seeeven more innovativeapplications in healthcare,from personalized drugdelivery systems toregenerative medicine. Theintegration of 3D printing inhealthcare is not just atechnological advancement;it's a paradigm shift thatpromises to enhance patientcare, reduce costs, and pushthe boundaries of what'spossible in modern medicine.We hope you enjoy thisedition. Please send usinteresting breakthroughstories about technologiesyou encounter. Your insightsand experiences couldinspire others and contributeto our tech enthusiastcommunity. We'reparticularly interested inreal-world applications thathave made a significantimpact. Share your thoughtson potential futuredevelopments or challenges.Your perspective could sparkmeaningful discussions.Remember, everybreakthrough starts with anidea, and your story could bethe catalyst for the next biginnovation. Reach out to usto share your stories.Industrial Guide AsiaPublisher’sPublisher’sNoteNote
Page 1Stratasys, Inc., theoriginal patent holder forFDM (filament materialextrusion) 3D printingtechnology, has filed asignificant lawsuit forpatent infringement inthe United States DistrictCourt for the EasternDistrict of Texas, MarshallDivision.Insight OutStratasys files patent infringement lawsuit againstBambu LabThe lawsuit names severalentities associated withthe “Bambu Lab” brand asdefendants, includingShenzhen TuozhuTechnology Co., Ltd.,Shanghai LunkuoTechnology Co., Ltd.,Bambulab Limited, BeijingTiertime Technology Co.,Ltd., Beijing Yinhua LaserRapid Prototyping andMould Technology Co. Ltd.,and Tuozhu TechnologyLimited.Patents in 3D printing arecomplex, while severalviolations occur regularly,lawsuits usually happenonly when significantrevenues are involved andBambu Lab has beengenerating very significantrevenues. Stratasys, on theother hand, has beenstruggling with slowgrowth and in terms ofstock marketperformance. This case isalso somewhat remindfulof the one brought by 3DSystems against Formlabson SLA technology, whichwas resolved by Formlabspaying a royalty to 3DSystems for each machinesold.Stratasys, a company with a rich history in 3D printing technology since itsfounding in 1988, alleges that the defendants have infringed upon multiplepatents that Stratasys holds. The patents in question are related to variousaspects of 3D printing technology, including methods for printing three-dimensional parts, heated build platforms, and force detection mechanismsduring the printing process.The complaint outlines that the defendants, collectively referred to as“Bambu Lab,” have directly and indirectly infringed on several of Stratasys’spatents. These include U.S. Patent No. 9,421,713, which covers methods foradditive manufacturing using purge towers; U.S. Patent No. 9,592,660, relatedto heated build platforms in 3D printing; U.S. Patent No. 7,555,357, whichdetails extrusion-based layered deposition systems; U.S. Patent No. 9,168,698,concerning force detection in 3D printing; and U.S. Patent No. 10,556,381,which also pertains to force detection during fabrication.The prototyping lab at Whiskers, like many prototyping labs around the world, uses bothStratasys and Bambu Lab machines. From Zach Burhop’s LinkedIn post.Bambu Lab’s new A1, priced at $399.The lawsuit asserts that Bambu Lab’s products, including various 3D printerssuch as the X1C, X1E, P1S, P1P, A1, and A1 mini, infringe upon these patents. Thecomplaint details how these products allegedly use proprietary Stratasystechnologies without authorization, specifically noting the use of heatedbuild platforms, force detection systems, and purge towers that are integralto the patented processes and methods owned by Stratasys.
Page 2Insight OutThis lawsuit underscores the ongoingchallenges within the rapidly evolving 3Dprinting industry, where companies mustnavigate complex intellectual propertylandscapes. If successful, Stratasys could notonly receive substantial financial compensationbut also limit the operations of Bambu Lab in theU.S. market. The outcome of this case couldhave broader implications for the 3D printingindustry, particularly concerning theenforcement of patents and the protection oftechnological innovations. As the caseprogresses, it will be closely watched by industrystakeholders and legal experts alike.The case, Stratasys, Inc. v. Shenzhen TuozhuTechnology Co., Ltd., et al., Civil Action No. 2:24-cv-644, will proceed in the Eastern District ofTexas, with Stratasys demanding a jury trial. Thecase could set important precedents in patentlaw, particularly in the realm of high-techmanufacturing and 3D printing.The lawsuit was filed in the Eastern District of Texas, ajurisdiction known for its robust handling of intellectualproperty cases, particularly patent litigation. Stratasysasserts that the court has jurisdiction due to thedefendants’ substantial business activities within thedistrict, including sales and distribution of the allegedlyinfringing products.Stratasys is seeking multiple forms of relief, including adeclaration that the defendants have infringed upon theasserted patents, damages for the infringement(including enhanced damages for willful infringement),and a permanent injunction preventing furtherinfringement of Stratasys’s patents by the defendants.Additionally, the company seeks attorneys’ fees andother associated costs.The lawsuit emphasizes that the alleged infringementhas caused significant damage to Stratasys, both interms of lost revenue and harm to its market position.The company also highlights that the defendants wereaware of the patents as of August 5, 2024, yet continuedtheir infringing activities.i3D MFG and EOS Ink Agreement for 12 EOS M400-4 Industrial 3D PrintersIntegrated 3D (i3D MFG), one of the largest metaladditive manufacturing (AM) organizations in NorthAmerica, and EOS, a leading supplier of responsiblemanufacturing solutions, took center stage at RAPID +TCT 2024 tradeshow to announce i3D’s signing of aletter of intent to purchase twelve (12) ultra-productive4-laser EOS M 400-4 metal 3D printers. The massiveinvestment will grow i3D’s all-EOS capacity to 36systems in their Redmond, Oregon, production facility.“i3D’s strong partnership with EOS has had a demonstrable impacton our ability to serve broad customer-based needs for complexmetal additive components. The combination of forward-thinking,resiliency, reliability and best-in-class technology is at the forefrontof why i3D continues to expand our relationship with EOS.”Erin Mastroni, CEO, i3DJamie Goettler, Chief Revenue Officer, BTX, MarieLanger, CEO, EOS, Erin Mastroni, CEO, i3D, andGlynn Fletcher, President, EOS North AmericaThe EOS M 400-4 continues to propel thegrowing demand for large parts, as well as truemetal AM production of complex, disruptiveparts.
Page 3Insight Out3DEO, headquartered in Los Angeles, California, USA, has announced astrategic partnership and investment with IHI Aerospace Co., Ltd. (IA),based in Koutou-ku, Japan. This multi-faceted, multi-phase deal isdesigned to enhance the adoption and application of AdditiveManufacturing technologies within IA. It integrates advanced AMcapabilities with the precision and tradition of Japan’s aerospacemanufacturing sector.Starting in 2013 with theacquisition of an EOS M 280,i3D has committed to EOS’Direct Metal Laser Solidification(DMLS®) laser powder bedfusion technology. i3D hassubsequently grown into amajor player in metal AM, withcustomers in a broadspectrum of industries, such asspace, medical devicemanufacturing, clean energy,and automotive. Additionally,i3D’s leadership in additivemanufacturing further unlockscapabilities to acceleratetechnological development forother customers under the BTXPrecision umbrella in theaerospace andsemiconductor industries.Those industries, along withthe significant growth inrockets, satellites, and defenseapplications, are propellingboth i3D’s and BTX’s dramaticgrowth in the high-precisionmanufacturing sector.With four 400-watt lasers anda 400x400x400 mm buildvolume, the EOS M 400-4 istailored for serial production ofmetal AM and canaccommodate processing ofa broad range of materials,including aluminum, copper,stainless, titanium, and toolsteels, among others.“We are deeply honoured to partner with IA, a company that shares our vision for thefuture of aerospace manufacturing,” Matt Petros, CEO and Co-founder of 3DEO,commented. “This partnership underscores the incredible progress and potential ofAdditive Manufacturing, especially when coupled with a highly collaborative design foradditive approach.”“This order is one of the largestsingle metal AM investments ever inNorth America. The fact that i3D isfully committed to EOS technologyis extremely gratifying. i3D’sextraordinary team, led by Erin, hasdriven dynamic, ambitious growth.The reliability of EOS systems andservices has been integral to theirprogress. There is an amazingcollaborative bond between our twocompanies. Strong, supportiverelationships at every level havehelped create the path to today’sannouncement.”Glynn Fletcher, President, EOSNorth America.3DEO Partners with IHIAerospace to Enhance Adoption ofAdditive Manufacturing in Japan’sAerospace SectorThe partnership aims to integrate the advanced capabilities of AdditiveManufacturing with the precision and tradition of Japan’s aerospacemanufacturing sector.By leveraging 3DEO’s patented technology, its Design for AdditiveManufacturing (DfAM) knowledge and IA’s engineering expertise, thepartners expect to make a lasting impact on the aerospace industry,enhancing capabilities and setting heightened standards formanufacturing.Payman Torabi, CTO and Co-founder of 3DEO, added, “Workingalongside IA presents an exceptional opportunity to apply our AdditiveManufacturing technologies to the aerospace sector. It’s acollaboration that stands to reduce time-to-market and driveinnovation.”
Page 5Insight OutADDiTEC partners withBharat Fritz Werner toRevolutionize AdditiveManufacturing withHybrid PlatformADDiTEC, a leading US-based additivemanufacturing company is proud to announce astrategic partnership with Bharat Fritz Werner Ltd.(BFW), the largest CNC manufacturer in India. Thiscollaboration marks a significant milestone in thefield of additive manufacturing, combining thestrengths of both companies to develop agroundbreaking Hybrid platform.The newly developed Hybrid platform integratesstate-of-the-art Liquid Metal Jetting (LMJ) andHigh-Power Laser Directed Energy Deposition (DED)technologies in a CNC machining system. This all-in-one system offers unprecedented flexibility andcapabilities, setting new standards for the additivemanufacturing industry and expanding the horizonsof what is possible when innovation pushes theboundaries of technology.Brian Matthews, CEO and Founder of ADDiTEC, commentedon the partnership: “We are thrilled to partner with BFW,combining our advanced additive manufacturing technologywith their extensive expertise in precision machine tools &engineering. This Hybrid platform represents a significant leapforward when compared to all other products on the market,providing a versatile solution that meets the evolving needs ofour additive industry.“Ravi Raghavan, Managing Director of BFW added: “Ourcollaboration with ADDiTEC is a testament to our commitmentto innovation and product excellence. By integrating cutting-edge additive manufacturing technologies with our industry-leading CNC machines, we are poised to revolutionize themanufacturing landscape, offering our customers unmatchedflexibility and performance.”Tucker Induction Systems and Nikon SLM SolutionsPioneer Copper Printing for Induction IndustryTucker Induction Systems, a leader in the inductionheating industry, announces a major advancement incopper printing through a strategic partnership withNikon SLM Solutions. This collaboration positions TuckerInduction Systems as a trail-blazer in the United States,offering advanced copper printing capabilities using theSLM®280 PS system.Copper printing in the U.S. is rare, but Tucker InductionSystems, through this partnership, is now capable ofprinting induction coils and copper parts. Thisdevelopment sets new standards in the industry,enabling efficient and high-quality production thatmeets the needs of various sectors.Joshua Tucker, Manager at Tucker Induction Systems, stated, "Weare excited to be one of the few companies in the U.S. printinginduction coils with copper. Our collaboration with Nikon SLMSolutions allows us to push the boundaries of what's possible in theinduction industry."
Page 6Insight OutThe partnership addresses asignificant gap in the market byoffering a reliable solution forcopper printing. This capabilitynot only enhances TuckerInduction Systems' productionefficiency but also opens newpossibilities for complex andhigh-performance designs.Rocky Tucker, Owner of Tucker InductionSystems, added, "Partnering with NikonSLM Solutions has enabled us to innovateand develop functional copper inductors.Their technology and eagerness tocollaborate have been key to our success."Charlie Grace, CCO at Nikon SLMSolutions, commented, "We are thrilled tosupport Tucker Induction Systems inpioneering copper printing for the inductionindustry. This partnership exemplifies ourcommitment to driving innovation anddelivering cutting-edge solutions thataddress the evolving needs of ourcustomers."Materialise and nTop have announced a pioneering collaborationto push the boundaries of what’s possible with additivemanufacturing (AM). The integration of nTop Core, nTop’s implicitmodeling API, with Materialise's Magics 3D Print Suite and NxG BuildProcessor, will allow manufacturers to accelerate the entire design-to-manufacturing process and enable the production of complexparts that were previously impossible to print. This collaborationhas already demonstrated success in producing a high-performance, 3D-printed cylinder head for Wärtsilä, significantlyenhancing cooling performance and reducing weight by 60%,which was printed by Nikon SLM Solutions. This partnership solves a common problem for complex, high-performance designs by enabling implicit design files to beexchanged between design and manufacturing teams andnatively processed for production without meshing or otherintermediate processes. In turn, this allows engineering teams todesign higher-performance parts with more features andcapabilities while assuring they can be produced precisely andeconomically.This new capability positionsTucker Induction Systems as aleader in copper printingtechnology. Their commitment toinnovation ensures that they willcontinue to meet and exceedcustomer expectations.Materialise and nTop Partnerto Push the Boundaries ofWhat’s Possible with AdditiveManufacturingCollaboration yields high-performance 3D-printed cylinder headfor Wärtsilä with enhanced cooling and 60% weight reduction
Page 7Insight OutnTop has developed a powerful new implicitmodeling kernel and corresponding file formatthat can characterize highly complex, high-performance geometries at a fraction of the sizeof traditional CAD or mesh-based files. Until now,high-performance product designs created innTop could not be natively processed by Magics,requiring time-consuming translations for buildpreparation and production. Materialise’s NxGBuild Processor is configurable software thattranslates large and complex 3D design files into3D printable instructions, optimizing andmanaging the 3D printing process from start tofinish. By integrating nTop’s design software withMaterialise’s Magics and NxG Build Processor,these designs can be easily transferred nativelyto Materialise Magics for fast, high-quality buildpreparation and slicing.Materialise and nTop collaborated with NikonSLM to produce a high-performance cylinderhead for Wärtsilä, a global leader in innovativetechnologies and lifecycle solutions in themarine and energy markets. On its journey toenable carbon-neutral shipping and energyproduction, Wärtsilä explored innovative designsto optimize the cooling performance of thecylinder head, achieving a 60% weight reductioncompared to the original design. This new designalso allowed the integration of up to tensubsystems into the final component, reducingassembly complexity and improving coolingperformance. Previously, the design complexityand file size of this innovative design made itimpossible to 3D print the part usingconventional large-scale AM technologies.However, by combining nTop’s design softwarewith Materialise’s Magics and NxG BuildProcessor, based on implicit modeling, itbecame possible to 3D print the part. The finaldesign was printed in Inconel 718 by Nikon SLM,using the largest metal printer on the market.3D printing the impossible: innovative3D-printed cylinder head for WärtsiläMeeting the challenges of printing larger andmore complex partsIn response to rising customer demand for printinglarger and more complex parts, machine builders havemade substantial investments in developing largerprinters with expanded print volumes and increasedlaser capacity. However, when working with complexgeometries and larger build sizes, the pre-processing ofslice files can be lengthy, sometimes taking days. Thisextended processing time increases the risk of systemcrashes, and the large file sizes associated with high-performance designs make it harder to move modelsbetween applications for design and build preparation,and the machines that will print them.Despite significant progress in expanding designcapabilities, the challenges in processing andmanufacturing have constrained designs, limiting thefunctionality and performance of 3D-printed parts. Thecollaboration between Materialise and nTop aims toovercome these limitations by providing an integratedsolution to streamline the processing of intricate andlarge design files, thereby unlocking new levels ofefficiency and innovation in 3D printing."At Materialise, we understand that the future of additivemanufacturing hinges on the ability to efficiently process highlycomplex files for high-performance parts,” said Udo Eberlein, VicePresident of Software at Materialise. “If our industry cannot keeppace with the growing demands for intricate designs and larger buildsizes, it becomes impossible to unlock the full potential of new AMapplications. Our collaboration with nTop represents a significantstep forward in breaking these barriers. By combining nTop'simplicit modeling kernel with Magics and our Next Gen BuildProcessor, we are enabling faster, more reliable design-to-manufacture workflows, paving the way for innovations that wereonce deemed impossible."“At nTop, we are committed to advancing the power ofcomputational design to production — which is why I’m so excitedabout our partnership with Materialise and integration of nTopimplicit models into Magics for manufacturing,” said BradleyRothenberg, Co-Founder and CEO of nTop. “This enables ourmutual customers to streamline the manufacturing of their mostcomplex designs.”
Page 8Insight OutMaterialise and nTop have launched an EarlyAccess Program to accelerate the adoption ofhigh-performance geometries in additivemanufacturing. Aimed at users pushing theboundaries of this technology, the programallows participants to tackle challenges,helping them enhance design-to-manufacturing workflows and overallperformance. Phase 1, starting in Q3 2024, willinvite 10 companies, with an additional 20companies joining in Q1 2025. Participants willbenefit from faster, higher-quality buildpreparation by integrating nTop’s implicitmodeling API within the Materialise Magics 3DPrint Suite, eliminating time-consumingimplicit-to-mesh conversions and streamliningthe additive manufacturing process. Early Access Program for enhancedadditive manufacturing workflows"Nikon SLM Solutions is excited to be the first early accesspartner for the new Materialise Build Processor that nativelyprepares builds for our NXG XII 600 directly from nTop,” saidNicolas Lemaire, Software Product Manager at Nikon SLMSolutions. “While Nikon SLM focuses on making the NXG XII 600the most productive AM solution with a build rate of 1000 ccm/hr,we are evaluating how the integration between nTop andMaterialise can streamline the design-to-production process.”
Page 10At the Farnborough International Airshow2024, Oerlikon and MTU Aero Engines haveagreed on the next phase of thecollaboration agreement signed at ParisAirshow 2023 to establish a smart andstandardized thermal spray factory of thefuture. Insight OutDigitalization in Aerospace: Oerlikon and MTUAero Engines initiate establishment of a smartthermal spray factoryBy leveraging this cutting-edge technologyand integrating digital processes, thecompanies aim to achieve anunprecedented level of productivity,efficiency, quality and transparencythroughout the entire production chain ofaerospace components.One important key element is achieving100% digital traceability on the part levelthrough the implementation of advancedmeasures by tracking every partthroughout the production process,ensuring complete transparency andaccountability. Another crucial componentis the creation of a digital twin, simulatingthe production of aerospace componentsto enable real-time monitoring, analysis,and optimization. Additionally, the projectwill incorporate health, safety, andsustainability initiatives, focusing onreducing environmental impact throughimproved energy efficiency and wastereduction.To address the complexity of the projecttasks and ensure seamless integration ofsystems and processes, Oerlikon and MTUwill establish a cross-functional projectteam. Both companies have affirmed theircommitment to innovation and change,challenging traditional practices andpushing boundaries to drive continuousimprovement and optimization.At the Farnborough International Airshow 2024, Toby Middlemiss(Head of Aerospace at Oerlikon) and Dr. Markus Zeis (SVPEnablement at MTU Aero Engines) shake hands on the next phase oftheir collaboration agreement to establish a smart thermal sprayfactory, marking a significant step towards digitalization inaerospace.The project will comprise distinct phases and deliverables,including system connectivity, bi-directional systemintegration, structured data mapping and architecture,data screening for anomaly detection using data science,and process adaptation featuring automatic improvementproposals, predictive maintenance, and processoptimization."We are excited to partner with Oerlikon to establish astate-of-the-art thermal spray factory," says Markus Zeis,SVP Enablement at MTU Aero Engines. "This initiativerepresents a major step forward in our efforts to enhanceefficiency, quality, and sustainability using thermal sprayproduction."Toby Middlemiss, Head of Aerospace at Oerlikon, says:"Collaborating with MTU Aero Engines on this project is a testamentto our shared commitment to innovation, excellence and digitalization.We look forward to leveraging our expertise and resources to create asmart factory that sets new standards in production processes of theaerospace industry."
Page 11NAMI purchased 3D Systems’ metal DMP Factory500 and DMP Flex 350 Dual solutions, andpolymer SLS 380 solution to produce parts forSaudi Electricity Company — improving supplychain efficiencyDemonstrates positive effects of manufacturinglocally and impact of making additivemanufacturing more accessible to catalyzeinnovation 3D Systems’ solutions driving growth of additivemanufacturing use in energy sector — totalmarket expected to grow to $17 billion by 2032Insight OutNAMI Selects 3DSystems’ Metal &Polymer AdditiveManufacturing Solutionsto Power StreamlinedSupply Chain for SaudiElectricity Company3D Systems (announced that National AdditiveManufacturing & Innovation Company (NAMI), anadditive manufacturing company based in SaudiArabia, has purchased multiple 3D Systems 3Dprinting technologies — DMP Factory 500, DMP Flex350 Dual, and SLS 380 — to support its recentlyannounced collaboration with the Saudi ElectricityCompany (SEC). Through this initiative, NAMI willleverage the power of 3D printing to create alocalized supply chain for spare parts for SEC, thelargest producer, transmitter, and distributor ofelectrical energy in the Middle East and North Africa.As part of the project, NAMI will create a digitalinventory system intended to not only reduceproduction time but also physical storagerequirements and cost. 3D Systems’ additivemanufacturing solutions, including its metal and “Our additive manufacturing solutions have demonstratedtheir value for improving supply chain efficiency andaccelerating innovation across a variety of industries,” saidReji Puthenveetil, EVP, additive solutions and chiefcommercial officer, 3D Systems. “The combination of reverseengineering designs for obsolete parts and additivemanufacturing helps extend the uptime and life of equipment.NAMI’s engineering and application capabilities combinedwith the power of our industry-leading 3D printing platformswill be invaluable tools to catalyze the collaboration withSEC. I’m looking forward to seeing how this work will notonly benefit SEC but also the services it provides to itscustomers.” polymer 3D printing technologies as well asNoSupports printing strategies developed by itsApplication Innovation Group, are renowned forenabling the efficient production of precise end-use parts. The combined expertise of NAMI and 3DSystems’ industry-leading 3D printing will helpdeliver high-performance components such aspump impellers, fuel burners, motor fans, heatsinks, and heat exchangers while reducing SEC’sphysical inventory requirements. This will enableSEC to mitigate supply chain risk while loweringcosts and driving efficiency.“Since NAMI’s inception, we have made significant progressin expanding the use of additive manufacturing within theregion,” said Mohammed Swaidan, chief executive officer,NAMI. “Our collaboration with SEC reinforces ourcommitment to address the energy sector, and 3D Systems’technology and applications expertise form the foundation ofa transformative solution. The work we are doing with SECwill not only enhance the reliability of SEC’s supply chain butalso drive substantial cost efficiencies and operationalimprovements.”NAMI is a joint venture between 3D Systems andSaudi Arabian Industrial Investments Company(Dussur) to play a pivotal role in realizing SaudiArabia’s Vision 2030 to build localized additivemanufacturing production capabilities with aninitial focus on the defense, energy, andmanufacturing sectors.According to Research and Markets, the additivemanufacturing market in the energy sector wasvalued at $2.6 billion in 2023 and is expected togrow to $17 billion by 2032. Additive Manufacturingis well-recognized for its ability to shorten designcycles and deliver high-quality, reliable, and high-performance components that meet or exceeddesign criteria. 3D Systems has extensiveexperience helping customers in this high-tech,fast-paced industry meet these goals through itsadditive manufacturing solutions comprisingmaterials, 3D printing technologies, software, andservices. As a result, energy companies canincrease fuel efficiency, lower maintenance costs,and reduce greenhouse gases.
Page 13Siemens and BAE Systemshave announced anagreement that will see thetwo businesses collaborateon innovation in engineeringand manufacturingtechnologies embracingdigital transformation, whilstleveraging digitalcapabilities throughoutprogram lifecycles.Insight OutSiemens and BAE Systems sign five-year agreementto collaborate to accelerate digital innovationThrough the agreement, SiemensDigital Industries and BAE Systemscommit to working together regionallyand internationally in the fields ofSustainability, Industrial Digitalisation,and Supply Chain Modernisation, todevelop a framework to acceleratethe commercial application benefitsto BAE Systems within technologyexploitation and adaptation.The framework for collaborationfollows decades of successfulpartnership between the twocompanies. This has included thedevelopment and delivery of a rangeof Siemens’ technology, knowledgesharing between engineers and jointshowcases of solutions at industryforums.The five-year agreement isdesigned to explore anddevelop a strategic blueprintfor engineering of the futureand factory of the futurecapabilities across design andmanufacturing disciplineswithin BAE Systems. This buildson and exploits the recentdeployment of Siemens’ NX™software for productengineering and Teamcenter®software for Product LifecycleManagement (PLM), from theSiemens Xcelerator portfolio ofindustry software. Edgecomputing solutions andtechnology validation havealso been successfully usedacross multiple catapult andtechnology centres.Siemens and BAE Systems willalso continue previous initiativesto innovate and develop newapproaches to digitalmanufacturing supporting theFactory of the Future initiativewithin BAE systems.Brian Holliday, managing director atSiemens Digital Industries in the UKand Ireland, said: “This agreementbuilds on a well-established, successfulcollaboration between BAE Systemsand Siemens, companies which shareambitions to promote manufacturingcareers and innovation. Technology istransforming manufacturing at anaccelerated pace and we are proud towork with BAE Systems at the leadingedge of Industry 4.0 in the UK.Operator calls up digital information from theautomated logistics store in the factory for livefactory data (Image credit: BAESystems/Mark Wright)
Page 14Insight OutHyundai E&C is a global leader in all areas of the constructionindustry. In particular, the company is leading the nuclear powerplant business, focusing on improving technology related to theentire cycle from construction to decommissioning. Hyundai E&Cachieved its first export of a Korean nuclear power plant in 2009and is currently expanding its nuclear power plant constructionbusiness to overseas markets.Since 1993, when it was approved as Korea's first nuclearaccredited inspection organization, KIMS has conductedconstruction, pre-operational, and in-service inspections for 25nuclear power plants in Korea and abroad, including the UAE-BNPP.In addition, as a comprehensive research institute specialized inmaterial technology, KIMS is focusing on the development ofspecial materials such as high-strength stainless steel (XM-19) andmulti-metal materials for SMR. The institute is also conductingresearch on next-generation nuclear power plant innovativemanufacturing technologies such as 3D printing, special welding,and PM-HIP to commercialize SMR and secure economic feasibilityIain Minton, TechnologyCapability Delivery Director atBAE Systems, said:“Collaborations like this help usdevelop and invest in digitalthread enabling technologies ina much more integrated andseamless way. Siemensunderstand the complexities ofour operating environment, sowe can very quickly mature anidea to the point where it is putinto practice, for example whenwe are looking to implement /optimise new engineering,support or manufacturingcapabilities. That’s the real valueof this collaboration – the trustand understanding we havebuilt together creates a reallypowerful force in driving resultsfor the aerospace sector.”Ben Sheath, vice president andmanaging director, UK & Ireland,Siemens Digital IndustriesSoftware, said. “We are pleasedto extend Siemens’ two-decadelong relationship with BAESystems as it continues todeliver on strategic plans tobuild the factory of the future.We look forward to workingalongside the team at BAESystems as they leverage thepower of Industry 4.0 to helpachieve the company’s digitaltransformation goals. This isanother great example of howleaders in aerospace arechoosing to partner withSiemens and adopt the SiemensXcelerator portfolio as thefoundation of their digitaltransformation.”“The partnership is a good example ofSiemens’ broader vision for how we wantto work with customers via SiemensXcelerator. which is built on digitalportfolio, eco-system thinking and adigital marketplace. The principle is thatby working together in a focussed way,we can accelerate the time to businessand sustainability benefits throughtechnology.”The Korea Institute of MaterialsScience signed an MOU withHyundai E&C for R&D onlarge nuclear power plant andSMR constructionOn July 23, the Korea Institute of Materials Science signed anMOU with Hyundai Engineering & Construction in the mainconference room at KIMS in Changwon, Gyeongnam Province, topromote cooperation in large-scale nuclear power plants andSMR construction technologies.
Page 15Insight OutGSK announced the US Food and DrugAdministration (FDA) has approvedJemperli (dostarlimab) in combinationwith carboplatin and paclitaxel(chemotherapy) followed by Jemperli asa single agent for the treatment of adultpatients with primary advanced orrecurrent endometrial cancer. Thisapproval broadens the previousindication for Jemperli plus chemotherapyto include patients with mismatch repairproficient (MMRp)/microsatellite stable(MSS) tumours who represent 70-75% ofpatients diagnosed with endometrialcancer and who have limited treatmentoptions. The supplemental BiologicsLicense Application (sBLA) supporting thisexpanded indication received PriorityReview and was approved ahead of thePrescription Drug User Fee Act action date.Through this agreement, the two organizations will △ establishinternational standards for nuclear power plant constructiontechnology and quality standards to improve the competitivenessof large NPP and SMR construction in overseas markets, △developeSMR construction materials and welding technology, △ work closelytogether to establish a stable supply system, △ conduct jointresearch and transfer of intellectual property (IP) technology,△ operate human resources support and mutual consultationbody, △ plan to actively promote technological exchange andeducation.Dr. Chul-jin Choi, the president of KIMS,said,“KIMS is working hard to developnext-generation nuclear materials andmanufacturing technology,”and added,“Through this MOU, we pledge to achievemutual cooperation and active exchanges,and to do our best to enhance the globalcompetitiveness of Korean nuclear powerplant construction technology.”US FDA expands Jemperli (dostarlimab) pluschemotherapy approval to all adult patients withprimary advanced or recurrent endometrial canceras the first and only immuno-oncology-basedtreatment to show an overall survival benefitHesham Abdullah, Senior Vice President, GlobalHead Oncology, R&D, GSK, said: “Jemperli pluschemotherapy is the first and only immuno-oncology regimen to show significant andmeaningful improvement in overall survival foradult patients with primary advanced or recurrentendometrial cancer regardless of biomarker status.We are thrilled this option is now available formore patients in the US, including the 70-75% withMMRp/MSS tumours where treatment optionshave been limited.”Today’s expanded approval is based on results from dualprimary endpoints of investigator-assessed progression-freesurvival (PFS) and overall survival (OS) from Part 1 of the RUBYphase III trial. RUBY Part 1 is the only clinical trial in this settingto show a statistically significant OS benefit in the fullpopulation of patients with primary advanced or recurrentendometrial cancer, demonstrating a 31% reduction in risk ofdeath (HR: 0.69; 95% CI: 0.54–0.89) compared tochemotherapy alone.At the 2.5-year landmark, 61% (95% CI: 54-67) of patients inthe Jemperli plus chemotherapy group compared to 49%(95% CI: 43-55) in the chemotherapy group were alive. Inaddition, a 16.4-month improvement in median OS wasobserved with Jemperli plus chemotherapy versuschemotherapy alone (44.6 months [95% CI: 32.6–NR] vs. 28.2months [95% CI: 22.1–35.6], respectively).
Page 16Insight OutThe median duration of follow-up wasmore than three years.1 The safetyand tolerability analysis from RUBYPart 1 showed a safety profile forJemperli and carboplatin-paclitaxelthat was generally consistent with theknown safety profiles of the individualagents. The most commontreatment-emergent adverse events(≥ 20%) in patients receiving Jemperliplus chemotherapy were nausea,alopecia, fatigue, peripheralneuropathy, anaemia, arthralgia,constipation, diarrhoea, myalgia, rash,hypomagnesemia, decreasedappetite, peripheral sensoryneuropathy and vomiting.Matthew Powell, MD, Chief, Division of Gynecologic Oncology, WashingtonUniversity School of Medicine, and US principal investigator of the RUBYtrial said: “The initial approval of Jemperli plus chemotherapy was practice-changing for patients with dMMR/MSI-H primary advanced or recurrentendometrial cancer and today’s expanded approval will offer even morepatients the opportunity for improved outcomes. This is the only immuno-oncology treatment regimen that has shown a statistically significant overallsurvival benefit for the full patient population, which is a meaningful stepforward in treating this challenging cancer.”Adrienne Moore, Survivor, Founding Member and President of EndometrialCancer Action Network for African-Americans (ECANA) said: “With thisexpanded approval for Jemperli plus chemotherapy, GSK is bringing a much-needed new treatment regimen to the endometrial cancer community that mayhelp patients with primary advanced or recurrent endometrial cancer livelonger, providing hope to patients and their families. Survivors and advocatesshould be excited by today’s news and especially delighted that this approvalmeans that more patients in the US who are diagnosed with endometrialcancer will have a new treatment option.” “Our unique, high-touch approach topharmacy care and intense focus oninnovation is reinventing the rolepharmacy plays in caring for peoplewith complex needs throughout theU.S., helping them live healthier andenjoy a better quality of life,” saidJohn Figueroa, CEO of AnewHealth.“With pharmacy fulfillment centersfrom coast to coast, our national scaleand reach allows us to meet patients’needs wherever they call home whilepositioning us to quickly scale andgrow, so we can make an even biggerimpact elevating healthcare forpatients and driving superior outcomesfor the healthcare organizations whosupport them.”ExactCare and Tabula RasaHealthCare Rebrand CombinedOrganization as AnewHealthExactCare and Tabula Rasa HealthCare (TRHC) announced the officiallaunch of their newly combined brand, AnewHealth—a leadingpharmacy care management company that specializes in caring forpeople with the most complex, chronic medical needs in home andcommunity-based settings.ExactCare and TRHC officially combined in November 2023 and havesince been working to integrate the two organizations. The launch ofAnewHealth marks a major milestone in this effort.Building on proven track records in advanced pharmacy care,AnewHealth has deep expertise in medication management,delivering an unparalleled combination of integrated clinicalpharmacy and technology solutions that optimize medication therapyand outcomes for people with the most complex, chronic care needs.The organization is licensed toserve patients in all 50 states,providing pharmacy carenationwide to more than100,000 people, primarilyMedicare and Medicaidbeneficiaries, through a strongnetwork of healthcare partners.This includes well-established,long-standing partnerships withmany of the top home healthproviders, primary and specialtycare providers, risk-bearingorganizations like PACE, andmanaged care plans,establishing a proven trackrecord of success that ispropelling growth.
Page 17Insight OutAnewHealth’s robust suite of solutions—which includes comprehensive clinical pharmacy care anddispensing, MedWise® science-based technology to personalize medication regimens, and full-servicepharmacy benefit management—helps partners achieve clinical, quality and financial goals includingimproved adherence, reduced unplanned facility utilization, lower all-cause mortality rates, reducedmedical expenditures, and lower total cost of care.“Our combined capabilities provide the support and comprehensive pharmacy care needed to ensure people with complex, chronicneeds receive the most beneficial medication therapy, reducing their risk of complications and avoidable ER visits and hospitalstays,” said Brian Adams, President of AnewHealth. “With better patient health and clinical outcomes, our partners seeunnecessary medical spend significantly decrease, allowing them to devote more resources to what matters most, which is caring fortheir participants and beneficiaries.”With the launch of the AnewHealth brand, the TRHC and CareVention HealthCare brand names will beretired, while the brands for ExactCare and CareKinesis pharmacies will continue to operate under theirrespective names.Spectrum Dynamics Medical and Hermes MedicalSolutions Enter into Partnership to Offer IntegratedSolution of the Hermia Software with the Veriton-CT ScannerSpectrum Dynamics Medical, a leadinginnovator in digital SPECT imaging systems andHermes Medical Solutions (HMS), a leader inmolecular imaging software development arenow partnering to offer an integrated vendor-neutral software solution for advancedprocessing, quantitative analysis and reviewingimages from the Spectrum Dynamic’s VERITON-CT scanner including access to dosimetryapplications for theranostics.Spectrum Dynamic’s customers will benefitfrom Hermia’s best-in-class nuclear medicineand dosimetry software applications to fullyleverage the unique technology and imagequality of VERITON-CT scans. HMS is committedto maintaining a vendor-agnostic approach.This means that users have the freedom tochoose any vendor’s imaging systems while stillbenefiting from Hermia’s advanced analyticaltools.“As an independent, vendor-neutral software company,HMS is committed to continuous development of best-in-class software tools for the advanced analysis of nuclearmedicine scans, including those from the latest scanningtechnology. We are therefore delighted to collaboratewith Spectrum Dynamics to provide their users with easy-to-use advanced software tools for all their clinicalapplications within nuclear medicine as well as dosimetryplanning and verification for theranostics.” declares TomFrancke, CEO at HMS.The two companies already have several joint customersuccess stories in North America and in Europe andthese partnerships should bring further possibilities forclinical advancements and workflow efficiencies.“Spectrum Dynamics is renowned for providing the bestDigital SPECT scanners in the market, distinguished byour advanced technology and superior performance.Hermes Medical Solutions brings to the table, top-tierpost-processing software that is essential for high-quality imaging and precise diagnostics. Together, weaim to revolutionize the applications of nuclear medicineand theranostics. This partnership will combine ourstrengths to enhance capabilities in advanced 4Ddynamic imaging and therapeutics, setting newstandards in the field of theranostics” says Gilad Yoeli,CEO of Spectrum Dynamics Medical.
Page 19Sarclisa induction treatment demonstratedsignificantly improved progression-free survival inpatients with newly diagnosed multiple myelomaeligible for transplantTechnology & ProductsNew results from the two-part, double-randomized, German-speaking MyelomaMulticenter Group (GMMG)-HD7 phase 3study show that Sarclisa (isatuximab) incombination with lenalidomide,bortezomib, and dexamethasone (RVd)during induction therapy in transplant-eligible, newly diagnosed multiplemyeloma (NDMM) significantly prolongedprogression-free survival (PFS) from firstrandomization, resulting in a statisticallysignificant and clinically meaningfulreduction in disease progression or death,compared to RVd induction regardless ofthe maintenance regimen. Full results willbe submitted for presentation at aforthcoming medical meeting.Dietmar Berger, MD, PhDChief Medical Officer and Global Head of Development at Sanofi“The GMMG-HD7 study was designed to better understand the distincteffect of targeting CD38 with Sarclisa in induction versus maintenancetreatment of transplant-eligible patients. These data build upon our beliefthat Sarclisa has the potential to be a best-in-class CD38 therapy thatcould improve long-term outcomes versus the standard-of-care for certainpatients. We look forward to the full data presentation and continuingour mission of helping make a meaningful difference for people livingwith multiple myeloma.”GMMG-HD7 is one of six phase 3 studies to report positiveresults for Sarclisa in patients with multiple myeloma, whichincludes four positive readouts of a Sarclisa-basedquadruplet in the frontline setting. The most recent includedresults from the IMROZ phase 3 study evaluating theinvestigational use of Sarclisa with VRd versus VRd forpatients with transplant-ineligible NDMM, demonstrating astatistically significant and clinically meaningfulimprovement in PFS and a higher proportion of patients withminimal residual disease (MRD) negativity.Hartmut Goldschmidt, MDPresident of GMMG, Professor of Medicine at theHeidelberg University Hospital (UKHD), Germanyand principal investigator of the study“Successful induction therapy is one of the mostcritical components to reduce the relapse orrecurrence risk in patients with newly diagnosedmultiple myeloma. While we observed thisinvestigational combination showed improvedminimal residual disease negativity rates in the bonemarrow, indicating potentially deeper responsesafter induction, further follow-up was needed tobetter understand how this translated to long-termoutcomes. These data provide evidence that the Isa-RVd regimen potentially improves progression-freesurvival in the frontline, transplant-eligiblepopulation and supports the potential of thisquadruplet to become a new standard-of-careinduction regimen in this treatment setting.”
Page 20Technology & ProductsIn December 2021, Sanofi and GMMG shared the results from part one, which met the primary endpoint ofMRD negativity after induction therapy and before transplant in NDMM patients. The GMMG-initiated study isbeing conducted in close collaboration with Sanofi based on jointly defined research. Sanofi providedfinancial support to GMMG for this study. The use of Sarclisa in combination with RVd is investigational andhas not been evaluated by any regulatory authority.While considered a rare disease, MM is the second most common hematologic malignancy,1 with more than180,000 new diagnoses of MM worldwide yearly.2 Despite available treatments, MM remains an incurablemalignancy in most patients with an estimated 61% five-year survival rate for newly diagnosed patients.3Since MM does not have a cure, most patients will relapse. Relapsed MM is the term for when the cancerreturns after treatment or a period of remission. Refractory MM refers to when the cancer does not respondor no longer responds to therapy.Fizik’s One-to-OneCreates CustomSaddles for RidersUsing CarbonTechnologySaddles are a crucial point of contactbetween riders and their bikes and canmake a huge difference in ridingexperience, comfort, and performance.Traditionally, saddles use uniform-density foam for padding and aremade into different sizes to fit differentischial bone widths and shapes.Sometimes inserts are added toprovide additional comfort in specificcontact spots. Riders may try multipleseats before finding the saddles that fittheir particular body characteristicsand riding position.Fizik has a track record of usingtechnology and data to createrevolutionary products. Using riderdata from their own testing andperformance enhancing technology,Powered by Carbon, Fizik has designedand produced multiple latticed saddlemodels using Carbon’s elastomericmaterials and the Carbon Digital LightSynthesis™ (Carbon DLS™) process.Because these designs weresuccessful, they felt confident in takingthe next step: custom saddles withtheir recently launched One-to-Oneproduct.Why Custom Saddles?Every cyclist is unique. Rider experience, sensitivity, history ofinjuries, body shape, riding goals, and more can all affect the waywe sit on the saddle. A good, accurate fit depends on manyfactors including the rider, bike geometry, intended use, saddleshape, and preferred riding position. A saddle designed for manycan provide a generic solution to very specific problems, but whenmore of these fit factors can be tuned specifically to the rider, itleads to a more comfortable ride and better performance.Understandably, some cyclists go on a long quest to find the rightsaddle.A customized approach would directly address each rider’scomfort and performance needs all at once. If Fizik could recordthe pressure a cyclist exerts on the saddle dynamically whileriding, and produce a map of their unique pressure profile, theycould then use this data to produce a custom, 3D-printed saddletopper.The SolutionFizik had already introduced its Adaptive 3D line of saddles usingCarbon DLS. Carbon’s portfolio of elastomeric materials, latticedesign software, and 3D printing technology allowed them todevelop a new saddle without the constraints or limitationsimposed by traditional production methods and materials. Theydesigned and manufactured multiple functional zones within thesaddle, joined together progressively and seamlessly in the samepadding. The next step for Fizik was developing a custom saddleoffering for their riders.
Page 21Technology & ProductsFizik collaborated withgebioMized, a leader inpressure map data, toengineer a system forcollecting pressure map datafrom riders to customize asaddle design with distinctivezonal cushioning tuned toadapt specifically to the rider’sbody.Additive manufacturing makesit easier to manufacture one-off production parts, asopposed to traditionalmanufacturing methods likeinjection molding, whichrequires a larger-scalecommitment and entails hightooling costs. Without theconstraints of batchproduction imposed byinjection molding methods,each 3D-printed saddlepadding can be unique, whichmeans it’s possible for saddlepadding to be producedbased on an individual rider’sspecifications. With this asFizik’s goal, they spent threeyears researching, developing,testing, and confirming aprocess through which theycould capture, interpret, andtranslate a rider’s personalpressure data into a 3D-printed saddle.If they could record thepressure a cyclist exerts on thesaddle dynamically whileriding, and map out a uniquepressure profile, they couldthen use this data to producea bespoke 3D-printed saddlepadding that offersunparalleled improvements inboth comfort andperformance.To capture such data, Fizikworked with gebioMized todevelop a pressure sensor matcapable of measuringpressure at 64 points spreadout across the saddle’ssurface, relaying data in real-time wirelessly. The mat isapplied on a saddle and thecyclist is positioned on it in hisor her normal riding style. Thisallows gebioMized’s softwareto capture pressuredistribution when static ordynamic and in a variety ofseating and handlebarpositions.Unlike traditional tools that aimto measure sit bone distanceor sacrum angle, measuringpressure while riding reflectsthe real sitting position on thebike and allows Fizik to identifythe parameters that mattermost, like indicators of stabilityon the saddle, peak pressureidentifiers and hotspots, andpelvic tilt.Riders can get measured andassessed easily on their ownbikes, which can be set up ona Wahoo Kickr Rollr at selectretailers. A trained bike fitterguides the One-to-One fitsession using a dedicatedmobile app. Relevantinformation about the rider’scurrent bike setup and saddleposition is gathered through asimple questionnaire, thenpressure data is captured onthe rider’s current bike andsaddle setup in all relevantriding positions.Pressure data from eachmeasurement session isrecorded while riding on thehandlebar tops, hoods, and inthe drop position for varioustypes of bikes. After processing,this data is cross-checked witha rider’s discipline and genderto ensure correctinterpretation.We know that a good, accurate fit depends onmany factors: bike geometry, intended use,saddle shape, and position. But most importantlyevery cyclist is unique: experience, sensitivity,history of injuries, body shape, riding goals. Allof this can affect the way we sit on the saddle.It’s clear that a traditional one-to-many saddledesign can only provide an approximate solutionto very specific problems. With One-to-Onetoday we achieve what every saddle manufacturerhas always dreamed of: bringing to lifecustomized support available to every cyclist.Giovanni FogalBrand Manager, FizikCapturing Rider Pressure DataTo create a truly custom saddle, a rider’spressure data must be captured,including the body force transferred tothe saddle as well as how that force isdistributed across the saddle’s surface.Of course, that pressure changescontinuously while riding, as the riderpedals and shifts riding positions, whichmeans it’s crucial to capture pressuremeasurements dynamically while inmotion and over time.
Page 22Technology & ProductsThe results are displayed in a pressure chart showing the meanpressure across the saddle, the front and rear and left and rightsaddle pressure comparisons, the maximum pressure values andtheir locations on the saddle, the center of movement and pelvictracking pattern, and the gross angle of pelvic hemispherealignment.Converting Data to DesignThe first step of a One-to-One measurement session is to matchthe rider with the ideal saddle shape. For this, Fizik developed amatching algorithm that takes into account all key parametersderived from initial data collection to determine the most suitablesaddle shape for a given load type and riding style.Pressure data is captured again on the rider’s current bike setupwith the recommended saddle shape in all relevant ridingpositions. These new measurements on the selected saddle shapeare used as the baseline to create the custom 3D-printed paddingstructure that reflects a rider’s specific needs, adapting to loadpattern, compensating asymmetries and hotspots, and addressinginstability.While additive manufacturing has enabled the production ofcustom parts, it has been tough to scale these products to datebecause of the manual work involved with adapting designs aswell.ProductionUtilizing the Carbon Custom Production Software offering, custom-latticed saddle toppers are then marked with a unique serialnumber, added to print projects, and sent to a production facilityvia a fully automated workflow.Ready to RideOnce the new One-to-One saddlehas been received and mounted onthe bike, the rider can return to thedealer for a final session whenpressure data will be captured on thenew saddle for comparison to theinitial saddle setup, highlighting allthe parameters that have improved.You can purchase a custom One-to-One saddle from any of the retailerslisted here, and learn more aboutCarbon’s Custom ProductionSoftware here.
Page 23Technology & ProductsSiemens Healthineers Offers NewWay to Detect a Broken Heart:NT‑proBNPII Assay Now Part ofAtellica Cardiac Testing Menu Siemens Healthineers has added the NT‑proBNPII (PBNPII) assay to itscomprehensive cardiac menu on the Atellica® Solution to help diagnoseheart failure. N-terminal proBNP (NT-proBNP) and Brain or B-type natriureticpeptides (BNP) are cardiac markers of stress that are released in responseto increased ventricular filling pressure. The PBNPII assay from SiemensHealthineers supports timely patient care with a 10-minute time-to-first-result. Siemens Healthineers now offers both natriuretic peptide tests tosupport choice and flexibility, as both assays can run on either thecompany’s Atellica® IM or Atellica® CI analyzer.In the United States, heart failure affects nearly 6.5 million adults anddirectly accounts for about 8.5 percent of all heart disease deaths.1 Bothacute and non-acute heart failure are difficult to diagnose because thesymptoms are similar to other health conditions. Elevated levels of eitherNT-proBNP or BNP are associated with heart failure, and they are bothrecommended biomarkers to aid in diagnosis. Natriuretic peptide assaysmake it possible to quickly, efficiently, and cost-effectively2 measure BNPand NT-proBNP concentration levels in the blood, helping enable cliniciansto more effectively diagnose heart failure and begin appropriatetherapeutic treatment. Using natriuretic peptide assays helps reduce timeto diagnosis and treatment, and can help significantly lower the rates ofmisdiagnosis.“The addition of the NT-proBNPII assay to the Atellicaplatform is an importantdevelopment,” said Dr. JamesJanuzzi, Professor of Medicine atHarvard Medical School, ChiefScientific Officer at the BaimInstitute for Clinical Research anda pioneer in natriuretic peptidetesting. “NT-proBNP is a valuableadjunct to clinical care of patientswith suspected or proven heartfailure in the ED and outpatientcare settings. Given the clinicalflexibility in choice of NT-proBNPand BNP on one instrumentcoupled with excellence and globalreach of Siemens Healthineerstechnology, this is a welcomeadvance for patient care.”Physicians typically requestblood tests to measurenatriuretic peptides forpatients presenting to theemergency department or inoutpatient settings withclinical suspicion of newonset or worsening heartfailure. With both NT-proBNPII and BNP assaysavailable alongsideguideline acceptable High-Sensitivity Troponin I on thehigh-volume AtellicaSolution and mid-volumeAtellica CI Analyzer, clinicallaboratories now havechoice and flexibility toconsider the testingpreferences of theirphysicians. This also helpssupport workflowstandardization and clinicalequivalence among satellitelaboratories—factors criticalto more efficient laboratoryoperations and patient carewithin a health network.Information about thecomplete cardiac menufrom Siemens Healthineers isavailable here.
Page 25This will be the 8th polymers event hosted by SCI’s All-Ireland andMaterials groups. This year’s conference will be an in-person eventheld at University College Dublin exploring the field of polymers andmaterials and their uses in additive manufacturing.This event will focus on sustainable developments in the field with afocus on the following areas;• Development of natural and biobased materials from 3D printing• Efficient manufacturing of materials from 3D printing• Efficient lightweight materials from 3D printing• Additive manufacturing processing of materials for energy storage• Analysis and characterisation of printed materialsJoin us to take part in discussions and talks on additive manufacturingand network with both academic and industrial researchers working inthe field.Great OpportunityAdvances in polymers and materialsfor additive manufacturing IIIMPC 2024: Advanced Materials for AdditiveManufacturing II: AM and SustainabilityAttendeesThis event is aimed atresearchers in the field ofpolymers and materials foradditive manufacturing (3Dprinting). It will bring togetherresearchers from bothacademia and industry todiscuss new developments andbuild networks in the field.Call for oral and poster presentationsContributions are invited from both academic and industrialresearchers working in the field of polymers and materials for additivemanufacturing to submit an abstract for an oral or posterpresentation. An abstract of maximum 250 words indicating title,authors, institution and preference for presentation option (oralpresentation or poster) should be sent to conferences@soci.org byFriday 28 June 2024 with the subject line “SCI Advances in Polymersand Materials for Additive Manufacturing - abstract submission”.Presentation slots are inevitably limited and will be allocated toachieve a balanced programme – researchers will be invited tocontribute a poster if submission is not chosen for oral presentation.Prizes will be awarded for the best presentation and poster. Anabstract template can be found here.HospitalManagementAsia 2024Don’t miss the largesthealthcare leadersgathering in Asia!A two day event on 28-29 Augin Bali, Indonesia with pre-event workshops on 27 Aug andhospital tours on 30 Aug. Joinus for a week of learning!
Page26The frenzy around healthcare’s digital transformation haslasted for years now. We’ve been looking to it as a solutionto many challenges the sector faces – the acute lack ofnurses and allied health workers, widening access to care,and meeting raising demand from ageing populations, toname a few. But what exactly does this digital transformation entail?We’ve realized that it goes beyond simply procuring theright technologies and digital solutions for the hospital. Atrue healthcare transformation also calls for changingmindsets, crafting novel processes, and building culturesand relationships. Great OpportunityHMA 2024 will showcase healthcareproviders in the region who have improvedoutcomes and experience not just forpatients but also for its staff using smarttechnology, and how they’ve been able toget past the mindset, culture andrelationship blocks. Why attend?Join us for 4 days of industry presentations,panel discussions and sharing of casestudies on these topics:Patient ExperienceQuality & SafetyLeading through changeCIO Summit, Nursing, and moreLearn practical and relevant best practicesfrom leading hospitals and solutionproviders.Network and forge partnerships with otherhospitals, technology vendors and solutionproviders, investors and governmentrepresentatives.Create meaningful transformation thatdelivers better care outcomes whileimproving patient experience.Welcome to the 2024 7thInternational Conference onHealthcare Service Management(ICHSM 2024), a premier gatheringof healthcare professionals, 7th International Conference on Healthcare ServiceManagementresearchers, technologists, and industry leaders dedicated toexploring the dynamic intersection of healthcare servicemanagement and cutting-edge technology. The international eventwill be held in Istanbul, Turkiye during September 6-8, 2024. As weconvene here today, we embark on a journey to delve into thetransformative power of digital innovation in reshaping the landscapeof healthcare delivery.
Page 27In recent years, the healthcare industryhas been undergoing a profound shiftpropelled by rapid advancements incomputer technology. From thedigitization of patient records to theemergence of telemedicine andartificial intelligence, digitaltransformation has become thecornerstone of modern healthcareservice management. This conferenceserves as a platform to navigate thistransformative journey, where we willexplore innovative strategies, sharebest practices, and envision the futureof healthcare delivery.Our theme, "Beyond the FutureHealthcare Service: EmpoweringHealthcare Through DigitalTransformation" encapsulates theessence of our collective mission. Weare here to celebrate the strides madein harnessing technology to enhancepatient care, optimize operationalefficiency, and drive positive outcomesacross the healthcare continuum.Throughout the conference, you willhave the opportunity to engage inthought-provoking discussions, attendenlightening presentations, andnetwork with peers who share apassion for leveraging technology toimprove healthcare delivery. Fromkeynote addresses by industryluminaries to interactive paneldiscussions and hands-on workshops,our program is designed to inspire,educate, and empower attendees tonavigate the complexities ofhealthcare service management in thedigital age.Great OpportunityMEDICAL FAIR ASIAAs we embark on this enriching journey together, let us embracethe spirit of collaboration, innovation, and commitment toexcellence. Together, we can harness the power of digitaltransformation to build a healthcare system that is moreaccessible, efficient, and patient-centered than ever before.Join us at MEDICAL FAIR ASIA – the region’s leading healthcareevent that connects you to a global MedTech audience. For thelatest in healthcare technology and innovations, medicalequipment, medical manufacturing, supplies and solutions, startplanning your participation today!Connecting you to a Global Community - Member ofMEDICALLIANCEWith presence in Bangkok, Bogotá, Moscow, Mumbai, New Delhi,São Paulo, Suzhou and Singapore, MEDICAL FAIR THAILAND is partof the MEDICAlliance global network under the Messe DűsseldorfGroup - which includes the world’s No.1 medical trade fair –MEDICA.Network with the industry and quality buyers: 60% (distributors,representatives, importers, exporters, wholesalers,manufacturers, trade) and 40% (hospitals, medicalestablishments, nursing homes, elder care services, governmentagencies and more).
Page 29The World Innovation Summit forHealth (WISH), an initiative of QatarFoundation, today announces thelaunch of its 2024 InnovationCompetition, inviting entrepreneursand startups to showcasegroundbreaking solutions that addressthe world's most urgent healthcarechallenges.Entrepreneurs in the health sector andrepresentatives from incubationcenters are encouraged to apply viahttps://wish.org.qa/innovation-competition-2024/. The deadline forapplications is July 15, 2024 andshortlisted projects will be announcedby August 2024.Early to mid-stage health-focusedstartups and innovators selectedthrough a judging process will beinvited to exhibit at the prestigiousWISH 2024 international healthcaresummit, set to take place on Nov. 13-14,at the Qatar National ConventionCentre, Doha.The WISH Innovation Competitioncomprises two categories: "YoungInnovators" for health startups led byfounders 30 years and younger; and"Innovation Showcases" for healthstartups that have moved beyond theideation phase and established theirmarket presence for up to five years.The winner in each category willreceive an investment award.Great OpportunityWISH Launches 2024 Competition on Healthcare-Related InnovationProposals can showcaseinnovative solutions acrossall spectrums of healthcare,with an emphasis on digitalhealth. The judgingcommittee will assessentries based on impact,novelty, and growthpotential.In addition to theinvestment award, keycompanion benefits of theWISH Innovation AwardProgram, whichincorporates the twocompetition categories,include networkingopportunities with like-minded startups, healthexperts, investors, and localincubation centers; andaccess to sessions withindustry experts to learnabout marketing, socialmedia, presenting, andpitching to investors.Winners will also receive aninvitation to showcase theirinnovations at WISH 2024,which will bring togetherhealthcare providers,ministers, insurers, investors,and industry experts.PManager of Policy and Content,WISH, Maha El Akoum expressedWISH's pride in announcing thelaunch of this years InnovationCompetition which seeks todiscover, support and propelforward the next generation ofhealthcare innovators.WISH believes that youngentrepreneurs are vital totransformative health solutions,and this competition aims toprovide them with a platform toshowcase their early-stagestartups. In addition, theInnovation Showcases categoryprovides a stage for establishedstartups to exhibit their novelsolutions and business models,she added.The WISH Innovation AwardProgram was launched in 2013and has supported a total of 148innovators from 36 differentcountries to date. Among thoseinnovations supported arepractical devices, design-basedsolutions, and integratedsoftware applications, all aimedat making global healthcaremore affordable, sustainable,and accessible.
Page 30Interested in revolutionising healthcare througheconomics? Stand a chance to win $3000 in theMOH-ESS Essay Competition! The Ministry of Health (MOH) and the EconomicSociety of Singapore (ESS) are calling on youngminds to participate and spark insightfuldiscussions on applying health economics toSingapore’s healthcare system.Great OpportunityMOH ESS EssayCompetition 2024As such, there is increasing pressure on thegovernment to ensure that healthcare resources areallocated fairly and efficiently across variousstakeholders in Singapore.Essay questions:How should the government allocate resources inour healthcare system amidst competing needssuch as those brought about by an ageingpopulation, as well as Singaporean's desire for highquality medical care?What are some of the principles the governmentcan adopt to ensure that healthcare resources areallocated in the best way possible to maximise thebenefits on health and well-being of Singaporeans?The essay should be well researched and provide freshperspectives. It should also be written in a way that isaccessible to a wide audience. Charts and tables maybe used, while equations (or derivations) should beavoided.The essay must be original in content. Entries found tocontain plagiarism will be disqualified. Although essaysmay draw on existing work, they should be materiallydifferent in terms of analysis, style of arguments,perspectives, or conclusions. A bibliographyacknowledging references to existing work is required.About MOH-ESS Essay Competition 2024Attractive AwardsThe winning essays will be selected by a panel ofjudges comprising representatives from the ESSand MOH. The following awards will be given tothe winning essays:Essay TopicResource Allocation in Singapore’s HealthcareSystemIn Singapore, the demand for healthcarecontinues to grow amidst our rapidly ageingpopulation. By contrast, the supply of healthcareresources is limited and sticky due to the time andeffort needed to train healthcare professionalsand build infrastructure.
Page 31This competition is opened toyouths aged 18 to 35 years old livingin Singapore, as well asSingaporean youths living abroad.The essay should not be more than2500 words and must be submittedno later than 13 August 2024, 2359(GMT +8).1. All entries must be accompaniedby a completed entry form(s),signed by the author(s). For jointauthorship, only one entry form isrequired. Submission on behalf ofan institution or firm is notpermitted.2. Members of the judgingcommittee (and their immediatefamily members) are not eligible toenter the essay competition.3. Entries must be in English andtyped double-spaced on one sideof each sheet of paper.The essayshould not be more than 2500words (to be strictly followed). Thisexcludes charts, tables, footnotes,references, and appendices.Great OpportunityRules and Regulations4. A summary of no more than 300 words highlighting the main pointsof the essay must also be provided. For submission, follow the formatas seen below:Cover page must contain the Essay Title and Author(s) and School(if applicable)SummaryContentsEssay should be submitted in word or pdf format only. Jpeg formatwill not be accepted.5. Entries should be sent online at esocsing@gmail.com. Essaysreceived on-line will be acknowledged.6. MOH-ESS Essay Competition Judging Committee reserves the rightnot to award any or all the prizes. The ESS also reserves the solecopyright to all submissions. All Entrants shall grant the EconomicSociety of Singapore a non-exclusive, royalty-free license to publishtheir Entry, in whole or in part, for any purpose, in any medium.7. Only winning participants will be contacted upon the finalisation ofthe results.8. The awards ceremony may be held in conjunction with theSingapore Economic Policy Forum. All prize-winning essays will beposted on the ESS websites.9. Please send any inquiries to the ESS-MOH Essay CompetitionCoordinator to the email address: esocsing@gmail.com
Page 323D printing is revolutionizing the healthcare industry, offeringinnovative solutions that were once unimaginable. Frompersonalized implants to custom prosthetics and beyond, thistechnology is paving the way for a new era in medical care. The Rise of 3D Printing in Healthcare3D printing, also known as additive manufacturing, involvescreating three-dimensional objects layer by layer from a digitalfile. In healthcare, this technology has gained significant tractiondue to its ability to produce customized medical devices,implants, and even tissues. The ability to tailor these products toindividual patients' needs is driving the adoption of 3D printingacross various medical fields.Personalized Implants and ProstheticsOne of the most significant advancements in 3D printing is theproduction of personalized implants and prosthetics. Traditionalmanufacturing methods often result in a one-size-fits-allapproach, which may not be ideal for every patient. 3D printing,on the other hand, allows for the creation of implants andprosthetics that are customized to the exact measurements ofthe patient. This not only improves the fit and comfort but alsoenhances the overall functionality of the device.For example, 3D-printed implants can be designed to match thepatient's anatomy precisely, reducing the risk of complicationsand promoting faster recovery. Similarly, prosthetics can betailored to the patient's specific needs, allowing for greatermobility and a more natural appearance.Feature Story3D Printing the Future ofHealthcare: Custom Solutionsand BeyondBioprinting: The Future of OrganTransplantsBioprinting is an exciting frontier in 3Dprinting technology, with the potentialto revolutionize organ transplants. Thisprocess involves printing layers ofliving cells to create tissues or evenentire organs. While still in theexperimental stage, bioprinting has thepotential to address the shortage ofdonor organs and reduce the risk oforgan rejection.Researchers are already makingsignificant strides in bioprinting. Forinstance, scientists have successfullyprinted blood vessels, skin, and evenminiature versions of human organs.As this technology continues toadvance, the possibility of printing fullyfunctional organs for transplantationcould become a reality, potentiallysaving countless lives.Custom Surgical Instruments3D printing is also being used to createcustom surgical instruments. Surgeonscan now design and print tools that aretailored to specific procedures,enhancing precision and reducing therisk of complications. Theseinstruments can be made on-demand,allowing for greater flexibility andefficiency in the operating room.In addition, 3D printing enables theproduction of complex instrumentsthat would be difficult or impossible tomanufacture using traditionalmethods. This opens up newpossibilities for innovative surgicaltechniques and procedures.
Page 33The Role of 3D Printing in Medical EducationBeyond patient care, 3D printing is playing acrucial role in medical education. Medical studentsand professionals can use 3D-printed models topractice procedures and study complex anatomy.These models provide a hands-on learningexperience that is far more effective thantextbooks or computer simulations.For example, surgeons can use 3D-printed replicasof a patient’s organs to plan and rehearsesurgeries, leading to better outcomes. Thisapplication of 3D printing not only enhancesmedical training but also improves patient safety.Overcoming Challenges and Looking AheadWhile 3D printing in healthcare offers immensepotential, it is not without challenges. The high costof equipment and materials, regulatory hurdles,and the need for specialized expertise are some ofthe barriers that need to be addressed. However,as the technology continues to evolve, thesechallenges are likely to diminish.The future of 3D printing in healthcare lookspromising. As advancements continue, we canexpect to see more personalized and efficienttreatments, improved patient outcomes, and asignificant reduction in healthcare costs. Thepotential for bioprinting and other innovationscould lead to breakthroughs that were once thestuff of science fiction.3D printing is undeniably transforming thehealthcare industry. From personalized implantsand prosthetics to bioprinting and custom surgicalinstruments, this technology is offering newpossibilities for patient care. As we look to thefuture, the continued development of 3D printingholds the promise of even greater advancements,ushering in a new era of personalized and efficienthealthcare solutions.Feature StoryPrototyping plays a crucial role in medicalmanufacturing, bridging the gap betweeninnovative ideas and market-ready products. Thisprocess, essential for bringing new medicaldevices and technologies to life, involves turningconceptual designs into tangible prototypes thatcan be tested, refined, and ultimately mass-produced. The Importance of Prototyping in MedicalManufacturingIn medical manufacturing, prototyping serves asthe foundation for developing new products.Whether it's a surgical instrument, diagnosticdevice, or implant, the prototyping phase is whereideas are transformed into physical models thatcan be evaluated for functionality, safety, andusability.Prototyping allows manufacturers to identifypotential design flaws, test different materials, andmake necessary adjustments before moving intofull-scale production. This iterative process is vitalfor ensuring that the final product meets stringentregulatory standards and performs as intended inreal-world medical applications.From Concept toReality: The Journey ofPrototyping in MedicalManufacturing
Page 34The Prototyping Process: From Concept toRealityThe journey from concept to reality in medicalmanufacturing typically involves several key stages:Conceptualization and Design: The processbegins with a conceptual design based onspecific medical needs or challenges. Engineersand designers work closely with healthcareprofessionals to develop a blueprint that outlinesthe product's features, dimensions, andfunctionality. Advanced software tools are oftenused to create 3D models that provide a detailedvisualization of the concept.1.Material Selection: Choosing the right materialsis critical in medical prototyping. The materialsmust be biocompatible, durable, and suitable forthe intended application. For example, implantsmay require materials like titanium or medical-grade polymers, while diagnostic devices mightuse plastics or silicone. The selection processinvolves rigorous testing to ensure the materialsmeet all necessary standards.2.Creating the Prototype: Once the design andmaterials are finalized, the prototype is created.This can be done using various techniques,including 3D printing, CNC machining, orinjection molding, depending on the complexityand requirements of the product. 3D printing, inparticular, has become a popular method due toits ability to produce intricate designs quicklyand cost-effectively.3.Testing and Validation: After the prototype isbuilt, it undergoes a series of tests to validate itsperformance, safety, and compliance withregulatory standards. This phase may involvemechanical testing, biocompatibilityassessments, and usability evaluations byhealthcare professionals. Feedback from thesetests is used to refine the prototype and makeany necessary modifications.4.Iterative Refinement: Prototyping is often aniterative process, with multiple rounds of testingand refinement. Each iteration brings theproduct closer to its final form, addressing anyissues that arise during testing. This stage iscrucial for optimizing the design and ensuringthat the product meets all functional andregulatory requirements.5.Finalization and Production: Once the prototypehas been thoroughly tested and refined, it isready for finalization. The design is locked in, andthe product moves into the manufacturingphase, where it is produced at scale fordistribution to healthcare providers and patients.6.Feature StoryThe Role of 3D Printing in Medical Prototyping3D printing has emerged as a game-changer in theprototyping process for medical manufacturing. Itsability to rapidly produce complex and customizeddesigns has significantly shortened the developmenttimeline, allowing manufacturers to bring products tomarket faster.In addition to speed, 3D printing offers unparalleledflexibility in design. Engineers can experiment withdifferent geometries and features without the need forexpensive tooling or molds. This makes it easier toiterate on designs and incorporate feedback fromtesting phases.Moreover, 3D printing allows for the creation ofpatient-specific prototypes, particularly in areas likeorthopedics and dental implants. By using patient-specific data from scans or imaging, manufacturerscan create prototypes tailored to the exact anatomyof the patient, leading to better fit and outcomes.Challenges in Medical PrototypingWhile prototyping is essential for innovation inmedical manufacturing, it comes with its own set ofchallenges. Regulatory requirements are stringent,and prototypes must undergo rigorous testing toensure they meet all necessary standards. This canbe time-consuming and costly, particularly whendealing with complex medical devices.Another challenge is the need for interdisciplinarycollaboration. Prototyping in medical manufacturingoften requires input from engineers, designers,healthcare professionals, and regulatory experts.Ensuring effective communication and coordinationamong these stakeholders is crucial for the success ofthe project.
Page 35The Future ofPrototyping in MedicalManufacturingAs technology continuesto evolve, the future ofprototyping in medicalmanufacturing lookspromising. Advances inmaterials science, 3Dprinting, and digitaldesign tools are making iteasier and faster todevelop high-qualityprototypes. Additionally,the integration of artificialintelligence and machinelearning into theprototyping process isexpected to furtherenhance efficiency andprecision.Looking ahead, thecontinued focus onpersonalized medicine islikely to drive demand forpatient-specificprototypes. This will notonly improve patientoutcomes but also pavethe way for moreinnovative and effectivemedical solutions.ConclusionPrototyping is the linchpinof innovation in medicalmanufacturing, turningvisionary concepts intopractical, life-savingproducts. Through arigorous and iterativeprocess, prototypes arerefined and perfected,ensuring that the finalproduct meets thehighest standards ofquality and safety. Astechnology advances, theprototyping journey willcontinue to evolve, drivingthe future of healthcareinnovation.Feature StoryRecent incidents involving counterfeitdrugs, contamination, and productrecalls have underscored theimportance of robust packagingsolutions. In response, pharmaceuticalcompanies are investing heavily inresearch and development to enhancepackaging safety, extend product shelflife, and improve patient outcomes.Innovations in PharmaceuticalPackaging: A Research-DrivenApproachThe pharmaceutical packagingindustry is undergoing a transformativephase, driven by advancements inmaterials science, digital technology,and regulatory compliance. Keyinnovations include:1. Advanced Barrier MaterialsRecent research in materials sciencehas led to the development ofadvanced barrier materials thatprovide superior protection against Packaging Precision—Ensuring Safetyand Integrity in PharmaceuticalProductsAs the pharmaceutical industrycontinues to innovate and expand,the need for precise, reliable, andsecure packaging solutions hasnever been more critical. Ensuringthe safety and integrity ofpharmaceutical products is not onlya regulatory requirement but also afundamental aspect of maintainingpublic health and trust. This pressdelves into the advanced strategies,technologies, and research effortsdriving the evolution ofpharmaceutical packaging,highlighting its crucial role insafeguarding patient well-being.The Critical Role ofPharmaceutical PackagingPharmaceutical packaging servesmultiple vital functions, fromprotecting products againstcontamination and degradation toensuring accurate dosing andfacilitating proper administration.The complexities involved inpackaging design, materialselection, and compliance withglobal regulatory standards requirea high level of precision andexpertise.
Page 362. Smart Packaging TechnologiesSmart packaging technologies arerevolutionizing the way pharmaceuticalproducts are monitored and managed.These technologies include embeddedsensors, RFID tags, and QR codes thatprovide real-time data on productconditions, such as temperature,humidity, and tampering.Recent studies highlight the potential ofthese technologies to improve supplychain transparency and reduce the riskof counterfeit drugs entering the market.By integrating smart packaging withblockchain technology, pharmaceuticalcompanies can create an immutablerecord of a product's journey frommanufacturer to patient, ensuring itsauthenticity and integrity.3. Child-Resistant and Senior-Friendly DesignsSafety is paramount in pharmaceuticalpackaging, particularly in preventingaccidental ingestion by children whileensuring ease of use for seniors.Research in ergonomic design andhuman factors engineering has led tothe development of packaging solutionsthat are both child-resistant and senior-friendly.Recent advances include the use ofdual-layer packaging with simple push-and-turn mechanisms, as well aspackaging that requires multiple,deliberate actions to access thecontents. These designs are rigorouslytested to meet international safetystandards while remaining accessible tothe elderly and those with physicallimitations.Feature StoryRecent research focuses onbiodegradable andrecyclable packagingmaterials that meetregulatory standardswithout compromisingproduct safety.One notable developmentis the use of plant-basedplastics and biopolymers,which offer a sustainablealternative to traditionalpetroleum-based plastics.These materials aredesigned to degrade morequickly in the environment,reducing the impact ofpharmaceutical packagingwaste.Furthermore,pharmaceutical companiesare exploring the use oflightweight packagingsolutions that minimizematerial usage and reducetransportation costs. Thisnot only contributes tosustainability goals but alsoenhances the overallefficiency of the supplychain.Conclusion: The Futureof PharmaceuticalPackagingThe pharmaceuticalpackaging industry is at theforefront of innovation,driven by the need toensure product safety,integrity, and compliancewith ever-evolvingregulatory standards.Through ongoing researchand the adoption ofcutting-edge technologies,the industry is poised tomeet the challenges of thefuture while safeguardingpatient health.Regulatory Compliance andGlobal StandardsCompliance with global regulatorystandards is a cornerstone ofpharmaceutical packaging.Packaging must adhere to stringentguidelines set by regulatory bodiessuch as the U.S. Food and DrugAdministration (FDA), the EuropeanMedicines Agency (EMA), and theWorld Health Organization (WHO).Recent regulatory updatesemphasize the importance ofserialization, a process that assignsa unique identifier to each productpackage. Serialization helps trackand trace pharmaceutical productsthroughout the supply chain,preventing counterfeiting andensuring that only legitimateproducts reach patients.Pharmaceutical companies areinvesting in advanced serializationtechnologies, such as 2D barcodesand data matrix codes, which arecapable of storing large amounts ofdata in a compact format. Thesetechnologies are integral to meetingregulatory requirements andmaintaining the integrity of theglobal pharmaceutical supply chain.Sustainability in PharmaceuticalPackagingThe growing emphasis onsustainability is driving innovation inpharmaceutical packaging.Companies are increasinglyadopting eco-friendly materials andpractices to reduce theirenvironmental footprint.
Page 371. What are some of the most significant trendsand innovations you see shaping the future ofthe hygiene and packaging industry? With the advancement of technology and smartmanufacturing infrastructure and systems,adhesive solutions for the hygiene andpackaging industry will have to supportmanufacturing efficiency. We will need adhesivesolutions that can be more easily integratedwith smarter manufacturing practices to enablebusinesses to keep up with innovation whileaddressing sustainability goals. The choice ofadhesives should not be an afterthought butone that promotes greater efficiency.Moreover, the relentless focus on reducingenvironmental impact has also called for theincorporating sustainable manufacturingpractices. According to Honeywell and TheFuturum Group’s Q3 2023 EnvironmentalSustainability Index, 45-60% of APAC companiesachieved environmental sustainability targets inemissions reduction, circularity and recycling,pollution prevention, and energy evolution andefficiency. It also highlighted that APACcompanies have plans to increase investmentsin energy evolution and efficiency by over 50%within 2024. Although representing only a smallfraction of the objects they contribute to,adhesives can facilitate the transition tosustainable manufacturing by promotingreducibility. 22 MinutesMr. Rockey Ye, Headof Hygiene, Paper &Cardboard at BostikAPAC2. How do you ensure that Bostik's products meet thediverse needs of customers in the Asia Pacific region?Bostik is committed to delivering tailored solutions thataddress the unique requirements of our diversecustomer base across the Asia Pacific region. As aregion, while APAC is making strides in prioritizingsustainability goals and embracing sustainablemanufacturing, we are not leading in this aspect yet,with diverse policies surrounding sustainablemanufacturing, such as ASEAN’s Framework forCircular Economy. Hence, Bostik has set up anextensive network of local teams, which helps to ensurea deep understanding of the specific needs of thecountry.Collaboration is key in facilitating this to ensure ourteams stay agile and innovative in developing effectivesolutions for our local customers. Our product teamworks closely with the research chemists and materialscientists to share their inputs on customer needs, andour technical support teams work on pilot applicationsand bonding process optimisations to develop anddeliver cutting-edge solutions.
Page 383. What are the key differences and similarities in markettrends between your region and Japan, and how do you andMr. Ohno address these?The Asia Pacific regions present a complex and dynamiclandscape for the hygiene adhesive market. Based on the 2024Hygiene Adhesive Market Report by Mordor Intelligence,countries like China and Japan are experiencing an increase inthe ageing population, driving the demand for adultincontinence products in these regions. In contrast, markets inthe wider Asia Pacific region, like India, which are characterisedby high birth rates, are fuelling growth in the infant diapermarket.Despite the growing demands in different segments of thehygiene market, the need for sustainable, safe, affordable, andhigh-performing solutions remains a constant across theregions. To target these specific trends, our teams mustidentify the focus applications for each country. With Bostik’sexpertise in specialised materials science combined with ourindustrial DNA for over 130 years, we are equipped to tailorinnovative solutions to these market trends.4. Can you elaborate on the collaborative projects betweenBostik APAC and Bostik Japan, particularly those involvingcutting-edge adhesive technologies?We recently launched Bostik Kizen™ PAD across Japan and thewider APAC region, a pad attachment adhesive with aconsistent peel strength across a wide range of substrates.This adhesive solution enables manufacturers to reduce theamount of adhesive usage by 30% to produce 40% more pads.Mr Ohno and I, together with our teams, worked on this productto address both manufacturer and consumer needs –customer’s demand for softer, non-woven back sheets thatoffer no residue regardless of fabric choice andmanufacturer’s demand for more sustainable adhesives thatcan keep up with higher production rates and sustainabilitygoals. Besides that, we are excited to share that our teamsare now developing an adhesive solution for bookbindingapplications, slated to launch in the Chinese and Japanesemarkets. 22 MinutesOur product team realised that customerswere finding it increasingly difficult tobalance sustainability goals and the paceof FMCG production. This next-generationadhesive solution contains over 50% bio-based adhesive content, with anapplication temperature 10-20 °C lowerthan market solutions, designed to reducecarbon emissions.5. What are the most significant technicalhurdles you anticipate in developingnext-generation adhesives, and how isBostik APAC preparing to overcomethem?As more and more businesses strivetowards their sustainability goals,packaging manufacturers are looking intoincorporating more environmentallyfriendly options, resulting in saturation andacceleration of the market. The challengeis to create solutions that improveperformance while reducing costs, lowerpricing strategies, and offer new valuepropositions to customers. New entrantswill need to navigate these same pressuresand differentiate their offerings.On the adhesive front, it is up to our internalteams to work together to developadhesive solutions that are not justcompatible with the latest trends andtechnologies, but also help to enable theadoption of them. For instance, weunderstand that customers demandproducts packaged in recyclable,compostable, and bio-based materialswhile still reaping cost savings. As such, wehave developed our hot-melt adhesivetechnology for case and carton sealing,which increases production speeds,enhances food and consumer safety, andimproves aesthetics. We are alsoconstantly developing the next-generationversions of adhesive solutions, just like ourupcoming book binding solutions withrevised adhesive formulas. Please keep alook out for this product set to launch overthe next few months!
Page 391. Can you elaborate on the significance of the Hot-Melt Wetness Indicator (HMWI) technology and itsimpact on the hygiene market in Japan?Hot Melt Wetness Indicators (HMWI) are designed tochange colour when exposed to an insult from withinthe diaper. Recognising the need to make it easier tospot when diaper changes are needed, minimisepremature changing, and protect the wearer from skinirritation from prolonged exposure to wetness, Bostikwas the pioneering company that introduced the HotMelt Wetness Indicator (HMWI) technology to the Japanmarket in the 2000s. I was honoured to be a part of theteam and witness how Bostik became the sole supplierof HMWI in the 2000s.Over the years, the demand for this adhesivetechnology has grown across different disposable22 MinutesMr. Motoki Ohno, Head of Hygiene, Paper andCardboard at Bostik Japanhygiene products – diaper briefs for infants andpull-up underwear for adults with moderate toheavy incontinence – and our Research &Development (R&D) team strives to keep upwith constant product innovation.This is evident in our recent HMWI innovation,Bostik COLOR 3.0, abio-based Hot Melt WetnessIndicator (HMWI) adhesive. Previous generationsof HMWI adhesives in the market would appearyellow on the diaper surface and turn green orblue upon urine detection. Manufacturers wouldneed to work around the limitation in back sheetdesign due to the noticeable yellowappearance. With Bostik COLOR 3.0, they arenow able to use a HMWI that presents atransparent, neat, and clean appearance,resulting in more flexible designs and easymonitoring of diaper condition. While thisproduct was only launched in May2023, we’veseen many local customers implementing ourlatest HWMI technology to reap energy and costsavings. 2. What roles do sustainability andenvironmental considerations play in Bostik'sproduct development and market strategy?Sustainability and environmental considerationshave always been a priority at Bostik’s initialproduct development and market strategystages. Whether prolonging a product's life,reducing raw materials used and wastegenerated, or enabling better end-of-lifemanagement solutions by making recyclingeasier, Bostik's adhesive solutions are designedto help build a more sustainable world. Thisapproach begins at the onset of the productvalue chain, from the choice of raw materials tothe compatibility with waste managementsolutions. Our R&D team is always looking toimprove existing solutions and develop newones that enable sustainability. Bostik enablesour customers to do more with less adhesiveuse, reduce environmental impacts andemissions, and adopt sustainablemanufacturing practices and a circulareconomy. For instance, Bostik COLOR 3.0 is ournext-generation HMWI adhesive with over 50%bio-based content and an applicationtemperature that is 30°C lower than that ofother HMWI adhesives in the market.
Page 403. Looking ahead, what are your key priorities andgoals for Bostik Japan over the next few years?According to the 2024 Japan Adhesive Marketreport by Mordor Intelligence, the advancement inplastic recyclability is one of the key driving factorsleading to the growth of the packaging industry.Additionally, research firm Fuji Keizai indicated thatfrom 2022 to 2027, while Japan’s diaper market forbabies is expected to contract 8%, the adult diapermarket is set to grow 16%. This translates into anoverall increase in diaper solutions for the localmarket.With the rising demand for consumer goods andhygiene products, it’s important for Bostik Japan towork alongside our customers, continue adaptingour adhesive technology to various applications,and minimise waste generation from theseproducts. Hence, our key priority and goal is toenable customers in the packaging and hygienemarket, where products are primarily single-use,to do more with less and shift to using bio-basedmaterials to reduce the environmental impact.4. How has the hygiene market in Japan evolvedsince you introduced HMWI technology, and whatrole has Bostik Japan played in this evolution?Before Hot Melt Wetness Indicators (HMWI) wereintroduced in the market, diaper change onlyhappened when the wetness was seeping throughthe back sheets of diapers or when printeddesigns would fade as the product became wet.After introducing the HMWI technology in Japan inthe2000s, we see a drastic increase in consumerexpectations for hygiene, comfort, and aesthetics.The technology has allowed quicker detection ofinsults in hygiene articles, reducing the chance ofleaks and skin irritations for the user. Following this,consumers were keen to look for disposablehygiene products that gave a cleaner appearance– a HMWI indicator that would allow for moreapparent colour change, with better colourretention and flexible designs. Bostik Japan is apioneer in this technology to improve diaperperformances, with cleaner and clearer colourindications to deliver high diaper productperformance.5. How do you foresee the impact of globaleconomic trends on the hygiene and packagingindustry, and what strategies are youimplementing to navigate these changes?With an increased awareness of sustainability andconsumer safety, the hygiene and packagingindustry would require solutions that prioritise user’ssafety, deliver high performance and remain cost-effective for the manufacturer. Hence, adhesivesolutions that promote sustainable manufacturingand enable our customers to drive the circularity ofproducts are crucial. To navigate these challenges,we’ve developed the patented Bostik's Kizen™ hot-melt adhesive technology designed for applicationsin absorbent hygiene products, case and cartonsealing, medical packaging, food and beveragepackaging and pharmaceutical packaging. It delivers high performance while enhancingsustainability value for our customers by:Improving recycle-readiness formulations andcompostable orbio-based grades to adhere tohighly recycled corrugateReducing pop-opens and equipmentmaintenance issues that would consume moreenergyDecreasing cost-in-use with adhesive coatingweight reduction22 Minutes
E V E N T C A L E N D A RAugustP H A R M A T E C H E X P O &L A B T E C H E X P O 2 0 2 4H E L I P A D E X H I B I T I O NC E N T E R , G A N D H I N A G A R ,I N D I A0 8 - 1 0 A U G U S T 2 0 2 4S O L I D - S T A T E B A T T E R YS U M M I T 2 0 2 4I N T E R C O N T I N E N T A LC H I C A G O M A G N I F I C E N TM I L E , C H I C A G O , U S A1 3 - 1 5 A U G U S T 2 0 2 4SeptemberH Y D E R A B A DI N T E R N A T I O N A L M A C H I N ET O O L & E N G I N E E R I N G E X P O2 0 2 4H I T E X E X H I B I T I O N C E N T E R ,H Y D E R A B A D , I N D I A1 6 - 1 9 A U G U S T 2 0 2 4T H E E N E R G Y E X P O 2 0 2 4M I A M I A I R P O R TC O N V E N T I O N C E N T E R ,M I A M I , U S A2 0 - 2 2 A U G U S T 2 0 2 4P R E C I S I O N M A C H I N I N GE X P O C H I N A 2 0 2 4S H A N G H A I N E WI N T E R N A T I O N A L E X P OC E N T R E ( S N I E C ) ,S H A N G H A I , C H I N A0 3 - 0 5 S E P T E M B E R 2 0 2 4A I R T E C H N O L O G Y I NI N D U S T R Y 2 0 2 4F I L D E R S T A D T , G E R M A N Y 0 2 - 0 3 S E P T E M B E R 2 0 2 4M E T A L E X P O I S T A N B U L2 0 2 4I S T A N B U L E X P O C E N T E R( I S T A N B U L F U A RM E R K E Z I ) ,B A K I R K Ö Y / I S T A N B U L ,T U R K E Y 1 1 - 1 4 S E P T E M B E R 2 0 2 4T H E W A T E R E X P O 2 0 2 4M I A M I A I R P O R TC O N V E N T I O N C E N T E R ,M I A M I , U S A2 0 - 2 2 A U G U S T 2 0 2 4T O T A L P L A S T I C S E X P O2 0 2 4C O D I S S I A T R A D E F A I RC O M P L E X , C O I M B A T O R E ,I N D I A0 1 - 0 3 A U G U S T 2 0 2 4A U T O M A T I O N E X P O2 0 2 4I A M I A I R P O R TC O N V E N T I O N C E N T E R ,M I A M I , U S A2 0 - 2 2 A U G U S T 2 0 2 2I N T E R N A T I O N A LC O N F E R E N C E O NE L E C T R O N I C S A N D P O W E RE N G I N E E R I N G 2 0 2 4M O N T R E A L , C A N A D A 0 5 - 0 6 A U G U S T 2 0 2 4I N T E R N A T I O N A LW O O D W O R K I N G F A I R 2 0 2 4G E O R G I A W O R L D C O N G R E S SC E N T E R , A T L A N T A , U S A0 6 - 0 9 A U G U S T 2 0 2 4I N T E R N A T I O N A L P R I N T I N G ,P A P E R , P A C K A G I N GM A C H I N E R Y E X H I B I T I O N2 0 2 4M A L A Y S I A I N T E R N A T I O N A LT R A D E A N D E X H I B I T I O NC E N T R E , K U A L A L U M P U R ,M A L A Y S I A0 7 - 1 0 A U G U S T 2 0 2 4P L A S T I C S , P A C K A G I N G ,P R I N T I N G E X P O 2 0 2 4H E L I P A D E X H I B I T I O NC E N T E R , G A N D H I N A G A R ,I N D I A0 8 - 1 0 A U G U S T 2 0 2 4D E L H I W A T E R E X P O2 0 2 4P R A G A T I M A I D A N , N E WD E L H I , I N D I A2 8 - 3 0 A U G U S T 2 0 2 2E N V I R O N M E N TP R O T E C T I O NT E C H N O L O G YE X H I B I T I O N 2 0 2 4P R A G A T I M A I D A N , N E WD E L H I , I N D I A2 8 - 3 0 A U G U S T 2 0 2 2I N T E R N A T I O N A LE X H I B I T I O N &C O N F E R E N C E O N H E A TT R E A T M E N T 2 0 2 4B O M B A Y E X H I B I T I O NC E N T R E ( B E C ) , M U M B A I ,I N D I A0 3 - 0 6 S E P T E M B E R 2 0 2 4S P E A U T O M O T I V EC O M P O S I T E SC O N F E R E N C E &E X H I B I T I O N 2 0 2 4D I A M O N D B A N Q U E T A N DC O N F E R E N C E C E N T E R ,N O V I , U S A0 4 - 0 6 S E P T E M B E R 2 0 2 4N A T I O N A L C H E M I C A LI N D U S T R Y C O N F E R E N C E ,G U A N G Z H O UI N T E R N A T I O N A LE N V I R O N M E N T A LP R O T E C T I O NE X H I B I T I O N , C H E M I C A LE Q U I P M E N T E X H I B I T I O N2 0 2 4P O L Y W O R L D T R A D EC E N T E R , G U A N G Z H O U ,C H I N A0 8 - 1 0 S E P T E M B E R 2 0 2 4T H E M A R I N E & O F F S H O R EQ A T A R I N T E R N A T I O N A LC O N F E R E N C E & E X P O2 0 2 4S H E R A T O N G R A N D D O H AR E S O R T & C O N V E N T I O NH O T E L , D O H A , Q A T A R0 9 - 1 0 S E P T E M B E R 2 0 2 4F O U N D A T I O NE N G I N E E R I N G E X P O2 0 2 4T O K Y O B I G S I G H T ,K O T O , J A P A N1 8 - 2 0 S E P T E M B E R 2 0 2 4N P A C O N V E N T I O N &E X P O 2 0 2 4C A E S A R S P A L A C E , L A SV E G A S , U S A1 6 - 2 0 S E P T E M B E R 2 0 2 4H I G H - P R E C I S I O N &D I F F I C U L TM A N U F A C T U R I N GT E C H N O L O G Y S H O W2 0 2 4T O K Y O B I G S I G H T ,K O T O , J A P A N1 8 - 2 0 S E P T E M B E R 2 0 2 4
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